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Article

Elucidation of the full genetic information of Japanese rubella vaccines and the genetic changes associated with in vitro and in vivo vaccine virus phenotypes.

Vaccine - 24 Feb 2011

Otsuki Noriyuki, Abo Hitoshi, Kubota Toru, Mori Yoshio, Umino Yukiko, Okamoto Kiyoko, Takeda Makoto, Komase Katsuhiro

Abstract excerpt

Rubella is a mild disease characterized by low-grade fever, and a morbilliform rash, but causes congenital defects in neonates born from mothers who suffered from rubella during the pregnancy. After many passages of wild-type rubella virus strains in various types of cultured cells, five live attenuated rubella vaccines were developed in Japan. An inability to elicit anti-rubella virus antibodies in...

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PMID: 21251900
DOI: 10.1016/j.vaccine.2011.01.016

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