No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.

doi:10.1136/annrheumdis-2012-201932

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Article

No evidence of an association between mitochondrial DNA variants and osteoarthritis in 7393 cases and 5122 controls.

Annals of the rheumatic diseases - 1 Jan 2013

Hudson Gavin, Panoutsopoulou Kalliope, Wilson Ian, Southam Lorraine, Rayner Nigel W, Arden Nigel, Birrell Fraser, Carluke Ian, Carr Andrew, Chapman Kay, Deloukas Panos, Doherty Michael, McCaskie Andrew, Ollier William E R, Ralston Stuart H, Reed Mike R, Spector Tim D, Valdes Ana M, Wallis Gillian A, Wilkinson J Mark, Zeggini Eleftheria, Samuels David C, Loughlin John, Chinnery Patrick F

Abstract excerpt

OBJECTIVES: Osteoarthritis (OA) has a complex aetiology with a strong genetic component. Genome-wide association studies implicate several nuclear genes in the aetiology, but a major component of the heritability has yet to be defined at the molecular level. Initial studies implicate maternally inherited variants of mitochondrial DNA (mtDNA) in subgroups of patients with OA based on gender and specific joint...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22984172
DOI: 10.1136/annrheumdis-2012-201932
PMCID: PMC3551219

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