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Article

Molecular basis of drug resistance in A/H1N1 virus.

Journal of chemical information and modeling - 22 Oct 2012

Vergara-Jaque Ariela, Poblete Horacio, Lee Eric H, Schulten Klaus, González-Nilo Fernando, Chipot Christophe

Abstract excerpt

New mutants of human influenza virus (A/H1N1) exhibit resistance to antiviral drugs. The mechanism whereby they develop insensitivity to these medications is, however, not yet completely understood. A crystallographic structure of A/H1N1 neuraminidase has been published recently. Using molecular dynamic simulations, it is now possible to characterize at the atomic level the mechanism that underlies the loss of...

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Identifiers

PMID: 22978683
DOI: 10.1021/ci300343w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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