Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status.

doi:10.1136/jmedgenet-2011-100716

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Article

Prediction of breast cancer risk by genetic risk factors, overall and by hormone receptor status.

Journal of medical genetics - 1 Sept 2012

Hüsing Anika, Canzian Federico, Beckmann Lars, Garcia-Closas Montserrat, Diver W Ryan, Thun Michael J, Berg Christine D, Hoover Robert N, Ziegler Regina G, Figueroa Jonine D, Isaacs Claudine, Olsen Anja, Viallon Vivian, Boeing Heiner, Masala Giovanna, Trichopoulos Dimitrios, Peeters Petra H M, Lund Eiliv, Ardanaz Eva, Khaw Kay-Tee, Lenner Per, Kolonel Laurence N, Stram Daniel O, Le Marchand Loïc, McCarty Catherine A, Buring Julie E, Lee I-Min, Zhang Shumin, Lindström Sara, Hankinson Susan E, Riboli Elio, Hunter David J, Henderson Brian E, Chanock Stephen J, Haiman Christopher A, Kraft Peter, Kaaks Rudolf

Abstract excerpt

OBJECTIVE: There is increasing interest in adding common genetic variants identified through genome wide association studies (GWAS) to breast cancer risk prediction models. First results from such models showed modest benefits in terms of risk discrimination. Heterogeneity of breast cancer as defined by hormone-receptor status has not been considered in this context. In this study we investigated the predictive...

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Identifiers

PMID: 22972951
DOI: 10.1136/jmedgenet-2011-100716
PMCID: PMC3793888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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