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Article

Evidence that BRCA1- or BRCA2-associated cancers are not inevitable.

Molecular medicine (Cambridge, Mass.) - 6 Dec 2012

Levin Bess, Lech Denise, Friedenson Bernard

Abstract excerpt

Inheriting a BRCA1 or BRCA2 gene mutation can cause a deficiency in repairing complex DNA damage. This step leads to genomic instability and probably contributes to an inherited predisposition to breast and ovarian cancer. Complex DNA damage has been viewed as an integral part of DNA replication...

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Source

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Identifiers

PMID: 22972572
DOI: 10.2119/molmed.2012.00280
PMCID: PMC3521784

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22972572-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Lymphoblasts of women with BRCA1 mutations are deficient in cellular repair of 8,5'-Cyclopurine-2'-deoxynucleosides and 8-hydroxy-2'-deoxyguanosine.Semantic proximity Read ↗

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individualsSemantic proximity Read ↗

Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers.Semantic proximity Read ↗

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