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Article

Azole-resistant invasive aspergillosis in a patient with acute myeloid leukaemia in Germany.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin - 6 Sept 2012

Hamprecht A, Buchheidt D, Vehreschild J J, Cornely O A, Spiess B, Plum G, Halbsguth T V, Kutsch N, Stippel D, Kahl P, Persigehl T, Steinbach A, Bos B, Hallek M, Vehreschild M J

Abstract excerpt

We report the first culture-proven case of invasive aspergillosis (IA) caused by azole-resistant Aspergillus fumigatus in a patient with acute myeloid leukaemia in Germany. IA presented as breakthrough infection under posaconazole prophylaxis. Analysis of the resistance mechanism revealed the TR/L98H mutation in the cyp51A gene, which indicates an environmental origin of the strain. This case underscores the need...

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PMID: 22971327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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