Article
KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence.
Disease markers - 1 Jan 2012
Morris Charles P, Baune Bernhard T, Domschke Katharina, Arolt Volker, Swagell Christopher D, Hughes Ian P, Lawford Bruce R, McD Young Ross, Voisey Joanne
Abstract excerpt
KPNA3 is a gene that has been linked to schizophrenia susceptibility. In this study we investigated the possible association between KPNA3 variation and schizophrenia. To investigate a wider role of KPNA3 across psychiatric disorders we also analysed major depression, PTSD, nicotine dependent, alcohol dependent and opiate dependent cohorts. Using a haplotype block-based gene-tagging approach we genotyped six...
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