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Article

Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure

1 Feb 2008

Abstract excerpt

Elevated intraocular pressure (IOP) is the principal risk factor for glaucoma and results from excessive impedance of the fluid outflow from the eye. This abnormality likely originates from outflow pathway tissues such as the trabecular meshwork (TM), but the associated molecular etiology is poorly understood. We discovered what we believe to be a novel role for secreted frizzled-related protein-1 (sFRP-1), an...

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PMID: 18274669
DOI: 10.1172/jci33871

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