Article
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans.
The American journal of clinical nutrition - 1 Oct 2012
Sevastianova Ksenia, Santos Alexandre, Kotronen Anna, Hakkarainen Antti, Makkonen Janne, Silander Kaisa, Peltonen Markku, Romeo Stefano, Lundbom Jesper, Lundbom Nina, Olkkonen Vesa M, Gylling Helena, Fielding Barbara A, Rissanen Aila, Yki-Järvinen Hannele
Abstract excerpt
BACKGROUND: Cross-sectional studies have identified a high intake of simple sugars as an important dietary factor predicting nonalcoholic fatty liver disease (NAFLD). OBJECTIVE: We examined whether overfeeding overweight subjects with simple sugars increases liver fat and de novo lipogenesis (DNL) and whether this is reversible by weight loss. DESIGN: Sixteen subjects [BMI (kg/m²): 30.6 ± 1.2] were placed on a...
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