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Article

Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides.

Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012

Bali Jitin, Gheinani Ali Hashemi, Zurbriggen Sebastian, Rajendran Lawrence

Abstract excerpt

Alzheimer's disease (AD) is characterized by the presence of toxic protein aggregates or plaques composed of the amyloid β (Aβ) peptide. Various lengths of Aβ peptide are generated by proteolytic cleavages of the amyloid precursor protein (APP). Mutations in many familial AD-associated genes affect the production of the longer Aβ42 variant that preferentially accumulates in plaques. In the case of sporadic or...

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Identifiers

PMID: 22949636
DOI: 10.1073/pnas.1201632109
PMCID: PMC3458335

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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