Phosphoethanolamine Substitution of Lipid A and Resistance of<i>Neisseria gonorrhoeae</i>to Cationic Antimicrobial Peptides and Complement-Mediated Killing by Normal Human Serum

Abstract excerpt

The capacity of Neisseria gonorrhoeae to cause disseminated gonococcal infection requires that such strains resist the bactericidal action of normal human serum. The bactericidal action of normal human serum against N. gonorrhoeae is mediated by the classical complement pathway through an antibody-dependent mechanism. The mechanism(s) by which certain strains of gonococci resist normal human serum is not fully...

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