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Article

Evolution of vancomycin-resistant Enterococcus faecium during colonization and infection in immunocompromised pediatric patients.

Proceedings of the National Academy of Sciences of the United States of America - 26 May 2020

Chilambi Gayatri Shankar, Nordstrom Hayley R, Evans Daniel R, Ferrolino Jose A, Hayden Randall T, Marón Gabriela M, Vo Anh N, Gilmore Michael S, Wolf Joshua, Rosch Jason W, Van Tyne Daria

Abstract excerpt

Patients with hematological malignancies or undergoing hematopoietic stem cell transplantation are vulnerable to colonization and infection with multidrug-resistant organisms, including vancomycin-resistant Enterococcus faecium (VREfm). Over a 10-y period, we collected and sequenced the genomes of 110 VREfm isolates from gastrointestinal and blood cultures of 24 pediatric patients undergoing chemotherapy or...

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Identifiers

PMID: 32393645
DOI: 10.1073/pnas.1917130117
PMCID: PMC7261057

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