Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast Cancer

28 Aug 2012

Abstract excerpt

BACKGROUND: The CD44 transmembrane glycoproteins play multifaceted roles in tumor progression and metastasis. CD44 expression has also been associated with stem-like breast cancer cells. Hypoxia commonly occurs in tumors and is a major cause of radiation and chemo-resistance. Hypoxia is known to inhibit differentiation and facilitates invasion and metastasis. Here we have investigated the effect of hypoxia on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22937154
DOI: 10.1371/journal.pone.0044078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypoxia Regulates CD44 and Its Variant Isoforms through HIF-1α in Triple Negative Breast CancerPMID 22937154Read ↗

ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer modelsSemantic proximity Read ↗

CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markersSemantic proximity Read ↗

Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A reviewSemantic proximity Read ↗

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem CellsSemantic proximity Read ↗

Functional Imaging of Hypoxia: PET and MRISemantic proximity Read ↗

Cell adhesion molecule CD44v10 promotes stem-like properties in triple-negative breast cancer cells via glucose transporter GLUT1-mediated glycolysisSemantic proximity Read ↗

Role of hypoxia-inducible factor-1α as a cancer therapy targetSemantic proximity Read ↗

The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7Semantic proximity Read ↗

CD44: A Multifunctional Mediator of Cancer ProgressionSemantic proximity Read ↗

Roles of hypoxia, stem cells and epithelial–mesenchymal transition in the spread and treatment resistance of head and neck cancerSemantic proximity Read ↗

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancerSemantic proximity Read ↗

Hypoxia Selectively Enhances Integrin α5β1 Receptor Expression in Breast Cancer to Promote MetastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.