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Article

γ-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)-S boundary.

The Journal of cell biology - 3 Sept 2012

Edgerton-Morgan Heather, Oakley Berl R

Abstract excerpt

A γ-tubulin mutation in Aspergillus nidulans, mipA-D159, causes failure of inactivation of the anaphase-promoting complex/cyclosome (APC/C) in interphase, resulting in failure of cyclin B (CB) accumulation and removal of nuclei from the cell cycle. We have investigated the role of CdhA, the A. ni...

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Source

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Identifiers

PMID: 22927465
DOI: 10.1083/jcb.201203115
PMCID: PMC3432763

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22927465-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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γ-Tubulin plays a key role in inactivating APC/C(Cdh1) at the G(1)-S boundary.PMID 22927465Read ↗

gamma-tubulin plays an essential role in the coordination of mitotic events.Semantic proximity Read ↗

Gamma-tubulin regulates the anaphase-promoting complex/cyclosome during interphase.Semantic proximity Read ↗

Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.Semantic proximity Read ↗

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The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers.Semantic proximity Read ↗

BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function.Semantic proximity Read ↗

Diminishing HDACs by drugs or mutations promotes normal or abnormal sister chromatid separation by affecting APC/C and adherin.Semantic proximity Read ↗

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Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells.Semantic proximity Read ↗

Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.Semantic proximity Read ↗

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