Article
Low penetrance alleles as risk modifiers in familial and sporadic breast cancer.
Familial cancer - 1 Dec 2012
Esteban Cardeñosa Eva, de Juan Jiménez Inmaculada, Palanca Suela Sarai, Chirivella González Isabel, Segura Huerta Angel, Santaballa Beltran Ana, Casals El Busto María, Barragán González Eva, Fuster Lluch Oscar, Bermúdez Edo José, Bolufer Gilabert Pascual
Abstract excerpt
The aim of the study is to investigate the relevance of rs1056663 and rs2708861 HUS1 polymorphisms, and rs104548, rs2981582 and rs2910164 polymorphisms of CASP8, FGFR2 and micro RNA 146A genes, respectively, as risk modifiers in hereditary breast or ovarian cancer (BC/OC) and risk factors in sporadic BC. We performed a case-control study in 189 healthy controls (CG) and 538 BC/OC cases, 340 with familial history...