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Article

TNF-α and IGF1 modify the microRNA signature in skeletal muscle cell differentiation

1 Jan 2015

Abstract excerpt

BACKGROUND: Elevated levels of the inflammatory cytokine TNF-α are common in chronic diseases or inherited or degenerative muscle disorders and can lead to muscle wasting. By contrast, IGF1 has a growth promoting effect on skeletal muscle. The molecular mechanisms mediating the effect of TNF-α and IGF1 on muscle cell differentiation are not completely understood. Muscle cell proliferation and differentiation are...

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PMID: 25630602
DOI: 10.1186/s12964-015-0083-0

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