Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle.

Immunogenetics - 1 Nov 2012

Wang Xiuge, Huang Jinming, Zhao Lihong, Wang Changfa, Ju Zhihua, Li Qiuling, Qi Chao, Zhang Yan, Zhang Zebin, Zhang Wei, Hou Minghai, Yuan Jinduo, Zhong Jifeng

Abstract excerpt

Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression levels of A2M mRNA and proteins in mastitis-infected mammary tissues. A2M mRNA and protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Macroglobulins
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cattle

Share to Mastitis, Bovine

Share to Real-Time Polymerase Chain Reaction

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Source

Identifiers

PMID: 22923050
DOI: 10.1007/s00251-012-0639-8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The exon 29 c.3535A>T in the alpha-2-macroglobulin gene causing aberrant splice variants is associated with mastitis in dairy cattle.PMID 22923050Read ↗

Regulatory mutations in the A2M gene are involved in the mastitis susceptibility in dairy cows.Semantic proximity Read ↗

Identification of splice variants, expression analysis and single nucleotide polymorphisms of the PRMT2 gene in dairy cattle.Semantic proximity Read ↗

DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows.Semantic proximity Read ↗

Identification of splice variants, targeted microRNAs and functional single nucleotide polymorphisms of the BOLA-DQA2 gene in dairy cattle.Semantic proximity Read ↗

Exploratory identification of coding and splicing-related SNV variants in A1A1 and A2A2 β-casein Holstein dairy cows.Semantic proximity Read ↗

Genetic polymorphisms of the BMAP-28 and MASP-2 genes and their correlation with the somatic cell score in Chinese Holstein cattle.Semantic proximity Read ↗

The Implication and Significance of Beta 2 MicroglobulinSemantic proximity Read ↗

Structural Investigations of Human A2M Identify a Hollow Native Conformation That Underlies Its Distinctive Protease-Trapping Mechanism.Semantic proximity Read ↗

One SNP in the 3'-UTR of HMGB1 gene affects the binding of target bta-miR-223 and is involved in mastitis in dairy cattle.Semantic proximity Read ↗

Role of an SNP in Alternative Splicing of Bovine NCF4 and Mastitis Susceptibility.Semantic proximity Read ↗

Do non-bovine domestic animals produce A2 milk?: an in silico analysis.Semantic proximity Read ↗

[Alpha-2 Macroglobulin Serum Level in Patients with Alpha-1 Antitrypsin Deficiency].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.