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Article

CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.

Biochimica et biophysica acta - 1 Jan 2000

Valli Emanuele, Trazzi Stefania, Fuchs Claudia, Erriquez Daniela, Bartesaghi Renata, Perini Giovanni, Ciani Elisabetta

Abstract excerpt

Mutations in the CDKL5 (cyclin-dependent kinase-like 5) gene are associated with a severe epileptic encephalopathy (early infantile epileptic encephalopathy type 2, EIEE2) characterized by early-onset intractable seizures, infantile spasms, severe developmental delay, intellectual disability, and...

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Source

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Identifiers

PMID: 22921766
DOI: 10.1016/j.bbagrm.2012.08.001
PMCID: PMC3787793

Genes

CDKL5
MYCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22921766-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells.PMID 22921766Read ↗

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.Semantic proximity Read ↗

Cell cloning-based transcriptome analysis in cyclin-dependent kinase-like 5 mutation patients with severe epileptic encephalopathy.Semantic proximity Read ↗

Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.Semantic proximity Read ↗

CDKL5-Related Disorders: From Clinical Description to Molecular GeneticsSemantic proximity Read ↗

CDKL5 ensures excitatory synapse stability by reinforcing NGL-1-PSD95 interaction in the postsynaptic compartment and is impaired in patient iPSC-derived neurons.Semantic proximity Read ↗

CDKL5 phosphorylates neuronal ELAVL proteins to promote mRNA binding, protein synthesis and visual cortex developmentSemantic proximity Read ↗

Epileptic Encephalopathy Caused by Mutations in the Guanine Nucleotide Exchange Factor DENND5A.Semantic proximity Read ↗

CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.Semantic proximity Read ↗

A kinase of many talents: non-neuronal functions of CDK5 in development and diseaseSemantic proximity Read ↗

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Semantic proximity Read ↗

Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal DevelopmentSemantic proximity Read ↗

CDKL5 deficiency disorder: At the intersection between Rett syndrome and developmental epileptic encephalopathies.Semantic proximity Read ↗

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