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Article

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder.

Fertility and sterility - 1 Nov 2012

Treff Nathan R, Campos Jessyca, Tao Xin, Levy Brynn, Ferry Kathleen M, Scott Richard T

Abstract excerpt

OBJECTIVE: To evaluate the utility of trophectoderm biopsy for preimplantation genetic diagnosis (PGD) of mitochondrial (mt) DNA mutation load. DESIGN: A PGD case and analysis of blastocyst mosaicism. SETTING: Academic center for reproductive medicine. PATIENT(S): A 30-year-old carrier of 35% 3243A>G mtDNA mutation load with a daughter affected by mitochondrial encephalomyopathy, lactic acidosis, and stroke-like...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22921075
DOI: 10.1016/j.fertnstert.2012.07.1119

Genes

PGD

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