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Article

Efficient differentiation of mouse embryonic stem cells into insulin-producing cells.

Experimental diabetes research - 1 Jan 2012

Liu Szu-Hsiu, Lee Lain-Tze

Abstract excerpt

Embryonic stem (ES) cells are a potential source of a variety of differentiated cells for cell therapy, drug discovery, and toxicology screening. Here, we present an efficacy strategy for the differentiation of mouse ES cells into insulin-producing cells (IPCs) by a two-step differentiation protocol comprising of (i) the formation of definitive endoderm in monolayer culture by activin A, and (ii) this monolayer...

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Identifiers

PMID: 22919367
DOI: 10.1155/2012/201295
PMCID: PMC3420137

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