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Directed differentiation of mouse embryonic stem cells into pancreatic-like or neuronal- and glial-like phenotypes.

Tissue engineering - 1 Oct 2007

McKiernan Eadaoin, O'Driscoll Lorraine, Kasper Michael, Barron Niall, O'Sullivan Finbarr, Clynes Martin

Abstract excerpt

The derivation of definitive endoderm and in particular endocrine cell types from undifferentiated embryonic stem (ES) cells remains difficult to achieve. In this study, we investigated the potential to regulate the differentiation of ES cells into endodermal derivatives using extracellular factors previously associated with various aspects of pancreatic development. Feeder-free-cultured mouse ESD3 cells were...

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PMID: 17655486
DOI: 10.1089/ten.2006.0373

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