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Differentiation of Mouse Embryonic Stem Cells into Endoderm without Embryoid Body Formation

30 Nov 2010

Abstract excerpt

Pluripotent embryonic stem cells hold a great promise as an unlimited source of tissue for treatment of chronic diseases such as Type 1 diabetes. Herein, we describe a protocol using all-trans-retinoic acid, basic fibroblast growth factor and dibutyryl cAMP (DBcAMP) in the absence of embryoid body formation, for differentiation of murine embryonic stem cells into definitive endoderm that may serve as pancreatic...

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PMID: 21152387
DOI: 10.1371/journal.pone.0014146

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