Article
Haploidentical transplantation for hematologic malignancies: where do we stand?
Hematology. American Society of Hematology. Education Program - 1 Jan 2012
Fuchs Ephraim J
Abstract excerpt
The fundamental obstacle to the successful application of partially HLA-mismatched related donor, or HLA-haploidentical stem cell transplantation, is the strength of the host and donor T-cell response to allogeneic HLA molecules, which results in increased incidences of graft failure, GVHD, and nonrelapse mortality. The holy grail of haplo-SCT is to mitigate host-versus-graft and graft-versus-host responses while...
Topics
- Alleles
- Cyclophosphamide
- Female
- HLA Antigens
- Hematologic Neoplasms
- Histocompatibility
- Humans
- Immune System
- Lymphocytes
- Male
- Stem Cell Transplantation
- Stem Cells
- T-Lymphocytes
- T-Lymphocytes, Regulatory
- Tissue Donors
- Transplantation Conditioning
- Treatment Outcome