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Article

The circadian clock protects against ionizing radiation-induced cardiotoxicity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2020

Dakup Panshak P, Porter Kenneth I, Gajula Rajendra P, Goel Peeyush N, Cheng Zhaokang, Gaddameedhi Shobhan

Abstract excerpt

Radiation therapy (RT) is commonly used to treat solid tumors of the breast, lung, and esophagus; however, the heart is an unintentional target of ionizing radiation (IR). IR exposure to the heart results in chronic toxicities including heart failure. We hypothesize that the circadian system plays regulatory roles in minimizing the IR-induced cardiotoxicity. We treated mice in control (Day Shift), environmentally...

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Identifiers

PMID: 31919902
DOI: 10.1096/fj.201901850RR
PMCID: PMC9677419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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