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Article

Novel somatic mutations to PI3K pathway genes in metastatic melanoma.

PloS one - 1 Jan 2012

Shull Austin Y, Latham-Schwark Alicia, Ramasamy Poornema, Leskoske Kristin, Oroian Dora, Birtwistle Marc R, Buckhaults Phillip J

Abstract excerpt

BACKGROUND: BRAF(V600) inhibitors have offered a new gateway for better treatment of metastatic melanoma. However, the overall efficacy of BRAF(V600) inhibitors has been lower than expected in clinical trials, and many patients have shown resistance to the drug's effect. We hypothesized that somatic mutations in the Phosphoinositide 3-Kinase (PI3K) pathway, which promotes proliferation and survival, may coincide...

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Share to DNA Mutational Analysis
Share to MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins B-raf

Share to ras Proteins

Share to Sequence Homology, Amino Acid

Share to Sequence Homology, Nucleic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 22912864
DOI: 10.1371/journal.pone.0043369
PMCID: PMC3422312

Genes

BRAF
NRAS
IRS4
MTOR
NFKB1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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