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Article

Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases.

Human mutation - 1 Jan 2013

Bakker Janine L, van Mil Saskia E, Crossan Gerry, Sabbaghian Nelly, De Leeneer Kim, Poppe Bruce, Adank Muriel, Gille Hans, Verheul Henk, Meijers-Heijboer Hanne, de Winter Johan P, Claes Kathleen, Tischkowitz Marc, Waisfisz Quinten

Abstract excerpt

SLX4/FANCP is a recently discovered novel disease gene for Fanconi anemia (FA), a rare recessive disorder characterized by chromosomal instability and increased cancer susceptibility. Three of the 15 FA genes are breast cancer susceptibility genes in heterozygous mutation carriers--BRCA2, PALB2, and BRIP1. To investigate if defects in SLX4 also predispose to breast cancer, the gene was sequenced in a cohort of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22911665
DOI: 10.1002/humu.22206

Genes

SLX4
BRCA2
BRCA1
BRIP1
PALB2

Provenance

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Related research

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Research trail→

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Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases.PMID 22911665Read ↗

Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases.Semantic proximity Read ↗

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families.Semantic proximity Read ↗

Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families.Semantic proximity Read ↗

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Assessment of SLX4 Mutations in Hereditary Breast Cancers.Semantic proximity Read ↗

Whole exome sequencing reveals uncommon mutations in the recently identified Fanconi anemia gene SLX4/FANCP.Semantic proximity Read ↗

Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.Semantic proximity Read ↗

Novel germline PALB2 truncating mutations in African American breast cancer patients.Semantic proximity Read ↗

Analysis of PALB2/FANCN-associated breast cancer families.Semantic proximity Read ↗

Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer predisposition.Semantic proximity Read ↗

Mutations of the SLX4 gene in Fanconi anemia.Semantic proximity Read ↗

Significance of the Fanconi Anemia FANCD2 Protein in Sporadic and Metastatic Human Breast CancerSemantic proximity Read ↗

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