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Article

Assessment of SLX4 Mutations in Hereditary Breast Cancers.

PloS one - 1 Jan 2013

Shah Sohela, Kim Yonghwan, Ostrovnaya Irina, Murali Rajmohan, Schrader Kasmintan A, Lach Francis P, Sarrel Kara, Rau-Murthy Rohini, Hansen Nichole, Zhang Liyng, Kirchhoff Tomas, Stadler Zsofia, Robson Mark, Vijai Joseph, Offit Kenneth, Smogorzewska Agata

Abstract excerpt

BACKGROUND: SLX4 encodes a DNA repair protein that regulates three structure-specific endonucleases and is necessary for resistance to DNA crosslinking agents, topoisomerase I and poly (ADP-ribose) polymerase (PARP) inhibitors. Recent studies have reported mutations in SLX4 in a new subtype of Fanconi anemia (FA), FA-P. Monoallelic defects in several FA genes are known to confer susceptibility to breast and...

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Source

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Identifiers

PMID: 23840564
DOI: 10.1371/journal.pone.0066961
PMCID: PMC3694110

Genes

SLX4
MAF
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Assessment of SLX4 Mutations in Hereditary Breast Cancers.PMID 23840564Read ↗

Mutation analysis of the SLX4/FANCP gene in hereditary breast cancer.Semantic proximity Read ↗

Low prevalence of SLX4 loss-of-function mutations in non-BRCA1/2 breast and/or ovarian cancer families.Semantic proximity Read ↗

Analysis of the novel fanconi anemia gene SLX4/FANCP in familial breast cancer cases.Semantic proximity Read ↗

Analysis of SLX4/FANCP in non-BRCA1/2-mutated breast cancer families.Semantic proximity Read ↗

Exome sequencing identifies rare deleterious mutations in DNA repair genes FANCC and BLM as potential breast cancer susceptibility alleles.Semantic proximity Read ↗

Mutations of the SLX4 gene in Fanconi anemia.Semantic proximity Read ↗

Whole exome sequencing reveals uncommon mutations in the recently identified Fanconi anemia gene SLX4/FANCP.Semantic proximity Read ↗

Sequencing analysis of SLX4/FANCP gene in Italian familial breast cancer cases.Semantic proximity Read ↗

SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.Semantic proximity Read ↗

Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4Semantic proximity Read ↗

Evaluation of Fanconi Anemia genes in familial breast cancer predisposition.Semantic proximity Read ↗

Characterization of FANCL variants observed in patient cancer cells.Semantic proximity Read ↗

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