Article
1α,25(OH)(2)-Vitamin D3 increases dysferlin expression in vitro and in a human clinical trial.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Oct 2012
De Luna Noemi, Díaz-Manera Jordi, Paradas Carmen, Iturriaga Cristina, Rojas-García Ricardo, Araque Josefa, Genebriera Mireia, Gich Ignasi, Illa Isabel, Gallardo Eduard
Abstract excerpt
Dysferlinopathies are a heterogenous group of autosomal recessive inherited muscular dystrophies caused by mutations in DYSF gene. Dysferlin is expressed mainly in skeletal muscle and in monocytes and patients display a severe reduction or absence of protein in both tissues. Vitamin D3 promotes differentiation of the promyelocytic leukemia HL60 cells. We analyzed the effect of vitamin D3 on dysferlin expression...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.