Peroxisome proliferator‐activated receptor γ coactivator 1‐α gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post‐necrotic mdx mouse skeletal muscle

Abstract excerpt

Key points Mitochondria are increasingly implicated in the pathogenesis of Duchenne muscular dystrophy (DMD). However, the extent to which the multiple facets of mitochondrial function are altered remains uncertain due to the lack of detailed assessment. Peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC1α) was recently shown to improve muscle pathology in dystrophic muscle. However, the...

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