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Article

The IGF1 small dog haplotype is derived from Middle Eastern grey wolves.

BMC biology - 24 Feb 2010

Gray Melissa M, Sutter Nathan B, Ostrander Elaine A, Wayne Robert K

Abstract excerpt

BACKGROUND: A selective sweep containing the insulin-like growth factor 1 (IGF1) gene is associated with size variation in domestic dogs. Intron 2 of IGF1 contains a SINE element and single nucleotide polymorphism (SNP) found in all small dog breeds that is almost entirely absent from large breeds. In this study, we surveyed a large sample of grey wolf populations to better understand the ancestral pattern of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 20181231
DOI: 10.1186/1741-7007-8-16
PMCID: PMC2837629

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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