Article
A single IGF1 allele is a major determinant of small size in dogs.
Science (New York, N.Y.) - 6 Apr 2007
Sutter Nathan B, Bustamante Carlos D, Chase Kevin, Gray Melissa M, Zhao Keyan, Zhu Lan, Padhukasahasram Badri, Karlins Eric, Davis Sean, Jones Paul G, Quignon Pascale, Johnson Gary S, Parker Heidi G, Fretwell Neale, Mosher Dana S, Lawler Dennis F, Satyaraj Ebenezer, Nordborg Magnus, Lark K Gordon, Wayne Robert K, Ostrander Elaine A
Abstract excerpt
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromos...
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