Article
Novel mutations in calcium/calmodulin-dependent protein kinase IV (CAMK4) gene in infertile men.
International journal of andrology - 1 Dec 2012
Khattri A, Reddy V P, Pandey R K, Sudhakar D V S, Gupta N J, Chakravarty B N, Deenadayal M, Singh L, Thangaraj K
Abstract excerpt
Calcium/calmodulin-dependent protein kinase IV (CAMK4) is a multifunctional serine/threonine protein kinase, which plays an important role in the spermatogenesis by phosphorylating protamines. It has been shown to be involved in the regulation of human sperm motility. Moreover, the Camk4 knockout mice were infertile because of severely reduced sperm count and morphological abnormalities. As no study is available...
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