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Article

Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males.

Molecular human reproduction - 1 Apr 2006

Christensen Greg L, Wooding Stephen P, Ivanov Ivaylo P, Atkins John F, Carrell Douglas T

Abstract excerpt

cAMP-responsive element modulator (CREM) is a key transcription factor in the differentiation of round spermatids into mature spermatozoa. During spermiogenesis, CREM is regulated in part by activator of CREM in the testis (ACT), which activates CREM in a phosphorylation-independent fashion. We hypothesized that the ACT gene, which is expressed exclusively in the testis, could be involved in male factor...

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PMID: 16687568
DOI: 10.1093/molehr/gal006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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