Article
Isoproteins and an isoelectric focusing mutant of human apoprotein serum amyloid A.
Electrophoresis - 1 Aug 1990
Steinmetz A, Schmidt B, Hocke G, Motzny S, Vitt H, Kaffarnik H
Abstract excerpt
On isoelectric focusing of human plasma and subsequent immunoblotting, using antii-human serum amyloid A (SAA) antibodies, a genetic variant of SAA was detected in a family of Turkish origin. All affected members of the family were apparent heterozygotes for the mutant protein, which underwent a charge shift of about one charge unit toward the anode. The variant is likely to be a mutant of the most prominent...
Topics
- Antibody Formation
- Blotting, Western
- Genetic Variation
- Humans
- Isoelectric Focusing
- Mutation
- Pedigree
- Sequence Homology, Nucleic Acid
- Serum Amyloid A Protein