Article
The myelin-deficient rat mutant: partial recovery of oligodendrocyte maturation in vitro.
Developmental neuroscience - 1 Jan 1990
Espinosa de los Monteros A, Zhang M, Gordon M N, Kumar S, Scully S A, de Vellis J
Abstract excerpt
The morphological and immunocytochemical identification and characterization of the myelin-forming cell, the oligodendrocyte, have defined a model system for developmental studies. The myelin-deficient (md) rat mutant lacks myelin in the central nervous system and fails to express the normal developmental increase in oligodendroglial and myelin markers, apparently as a consequence of a point mutation in the...
Topics
- Animals
- Astrocytes
- Biomarkers
- Cells, Cultured
- Demyelinating Diseases
- Fluorescent Antibody Technique
- Gene Expression Regulation, Enzymologic
- Glucosephosphate Dehydrogenase
- Immunohistochemistry
- Mutation