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Article

Structure and assembly of a paramyxovirus matrix protein

13 Aug 2012

Abstract excerpt

Many pleomorphic, lipid-enveloped viruses encode matrix proteins that direct their assembly and budding, but the mechanism of this process is unclear. We have combined X-ray crystallography and cryoelectron tomography to show that the matrix protein of Newcastle disease virus, a paramyxovirus and relative of measles virus, forms dimers that assemble into pseudotetrameric arrays that generate the membrane...

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PMID: 22891297
DOI: 10.1073/pnas.1210275109

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