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Prevalence and genetic diversity of candidate vaccine antigens among invasive Neisseria meningitidis isolates in the United States.

Vaccine - 24 Jun 2011

Wang Xin, Cohn Amanda, Comanducci Maurizio, Andrew Lubomira, Zhao Xin, MacNeil Jessica R, Schmink Susanna, Muzzi Alessandro, Bambini Stefania, Rappuoli Rino, Pizza Mariagrazia, Murphy Ellen, Hoiseth Susan K, Jansen Kathrin U, Anderson Annaliesa S, Harrison Lee H, Clark Thomas A, Messonnier Nancy E, Mayer Leonard W

Abstract excerpt

Neisseria meningitidis (Nm) serogroups B, C and Y are the major causes of meningococcal diseases in the United States. NmB accounts for ∼1/3 of the disease but no licensed vaccine is yet available. Two candidate vaccines are being developed specifically to target NmB, but may also provide protection against other serogroups. To assess the potential impact of these vaccines on NmB and other serogroups causing...

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PMID: 21571026
DOI: 10.1016/j.vaccine.2011.04.092

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