Article
Unmasking Hb Paksé (codon 142, TAA>TAT, α2) and its combinations in patients also carrying Hb Constant Spring (codon 142, TAA>CAA, α2) in northern Thailand.
Hemoglobin - 1 Jan 2012
Pornprasert Sakorn, Panyasai Sitthichai, Treesuwan Kallayanee
Abstract excerpt
The incidence of Hb Paksé (codon 142, TAA>TAT, α2) might have been underestimated due to misidentifying some cases as Hb Constant Spring (Hb CS, codon 142, TAA>CAA, α2) since both abnormal hemoglobins (Hbs) migrate to the same position on Hb electrophoresis or chromatography. Multiplex asymmetric allele-specific polymerase chain reaction (PCR) for identification of Hb CS and Hb Paksé, and a real-time PCR...
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