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Article

Classical macrophage activation up-regulates several matrix metalloproteinases through mitogen activated protein kinases and nuclear factor-κB.

PloS one - 1 Jan 2012

Huang Wei-Chun, Sala-Newby Graciela B, Susana Angela, Johnson Jason L, Newby Andrew C

Abstract excerpt

Remodelling of the extracellular matrix (ECM) and cell surface by matrix metalloproteinases (MMPs) is an important function of monocytes and macrophages. Recent work has emphasised the diverse roles of classically and alternatively activated macrophages but the consequent regulation of MMPs and their inhibitors has not been studied comprehensively. Classical activation of macrophages derived in vitro from...

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Identifiers

PMID: 22880008
DOI: 10.1371/journal.pone.0042507
PMCID: PMC3411745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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