Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.

PloS one - 1 Jan 2012

Price Gregory A, Holmes Randall K

Abstract excerpt

The secreted colonization factor, TcpF, which is produced by Vibrio cholerae 01 and 0139, has generated interest as a potential protective antigen in the development of a subunit vaccine against cholera. This study evaluated immunogenicity/protective efficacy of a TcpF holotoxin-like chimera (Tcp...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Suckling
Share to Cholera
Share to Cholera Toxin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunization

Share to Immunoglobulin A

Share to Injections, Intraperitoneal

Share to Vibrio cholerae

Share to Weight Loss

Source

Open in PubMed Open full text

Identifiers

PMID: 22879984
DOI: 10.1371/journal.pone.0042434
PMCID: PMC3413659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22879984-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of TcpF-A2-CTB chimera and evidence of additive protective efficacy of immunizing with TcpF and CTB in the suckling mouse model of cholera.PMID 22879984Read ↗

Maternal Vaccination with a Fimbrial Tip Adhesin and Passive Protection of Neonatal Mice against Lethal Human Enterotoxigenic Escherichia coli ChallengeSemantic proximity Read ↗

Inactivated Vibrio cholerae Strains That Express TcpA via the toxT-139F Allele Induce Antibody Responses against TcpA.Semantic proximity Read ↗

TcpF is a soluble colonization factor and protective antigen secreted by El Tor and classical O1 and O139 Vibrio cholerae serogroups.Semantic proximity Read ↗

Crystal structure of the Vibrio cholerae colonization factor TcpF and identification of a functional immunogenic site.Semantic proximity Read ↗

The role of toxin-coregulated pili in the pathogenesis of Vibrio cholerae O1 El Tor.Semantic proximity Read ↗

Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants.Semantic proximity Read ↗

A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in miceSemantic proximity Read ↗

Immunogenicity and protection induced by recombinant Toxocara canis proteins in a murine model of toxocariasisSemantic proximity Read ↗

Fusion proteins containing the A2 domain of cholera toxin assemble with B polypeptides of cholera toxin to form immunoreactive and functional holotoxin-like chimeras.Semantic proximity Read ↗

Native and mutant forms of cholera toxin and heat-labile enterotoxin effectively enhance protective efficacy of live attenuated and heat-killed Shigella vaccines.Semantic proximity Read ↗

Thymine auxotrophy as an attenuating marker in Vibrio cholerae.Semantic proximity Read ↗

Factors affecting the immunogenicity of tetanus toxin fragment C expressed in<i>Lactococcus lactis</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.