Article
Selfish spermatogonial selection: evidence from an immunohistochemical screen in testes of elderly men.
PloS one - 1 Jan 2012
Lim Jasmine, Maher Geoffrey J, Turner Gareth D H, Dudka-Ruszkowska Wioleta, Taylor Stephen, Rajpert-De Meyts Ewa, Goriely Anne, Wilkie Andrew O M
Abstract excerpt
The dominant congenital disorders Apert syndrome, achondroplasia and multiple endocrine neoplasia-caused by specific missense mutations in the FGFR2, FGFR3 and RET proteins respectively-represent classical examples of paternal age-effect mutation, a class that arises at particularly high frequencies in the sperm of older men. Previous analyses of DNA from randomly selected cadaveric testes showed that the levels...
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