Genetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.

doi:10.4161/pri.20785

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Article

Genetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.

Prion - 1 Jan 2000

Calero Olga, Bullido María J, Clarimón Jordi, Hortigüela Rafael, Frank-García Ana, Martínez-Martín Pablo, Lleó Alberto, Rey María Jesús, Sastre Isabel, Rábano Alberto, de Pedro-Cuesta Jesús, Ferrer Isidro, Calero Miguel

Abstract excerpt

Perturbations of calcium homeostasis have been associated with several neurodegenerative disorders. A common polymorphism (rs2986017) in the CALHM1 gene, coding for a regulator of calcium homeostasis, is a genetic risk factor for the development of Alzheimer disease (AD). Although some authors failed to confirm these results, a meta-analysis has shown that this polymorphism modulates the age at disease onset....

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Identifiers

PMID: 22874670
DOI: 10.4161/pri.20785
PMCID: PMC3609071

Genes

CALHM1
CALHM2
CALHM3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic variability of the gene cluster CALHM 1-3 in sporadic Creutzfeldt-Jakob disease.PMID 22874670Read ↗

Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis.Semantic proximity Read ↗

Genetic association of CALHM1 rs2986017 polymorphism with risk of Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk.Semantic proximity Read ↗

CALHM1 P86L polymorphism modulates CSF Aβ levels in cognitively healthy individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

No association between CALHM1 and risk for Alzheimer dementia in a Belgian population.Semantic proximity Read ↗

No association between CALHM1 polymorphism and Alzheimer's disease risk in a Hungarian population.Semantic proximity Read ↗

The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study.Semantic proximity Read ↗

No association between CALHM1 variation and risk of Alzheimer disease.Semantic proximity Read ↗

Lack of association between CALHM1 p.P86L variation and Alzheimer's disease in the Han Chinese population.Semantic proximity Read ↗

Calcium homeostasis modulator 1 gene P86L polymorphism and the risk for alzheimer's disease: A meta-analysis.Semantic proximity Read ↗

CALHM1 P86L polymorphism does not alter amyloid-beta or tau in cerebrospinal fluid.Semantic proximity Read ↗

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