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Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence

15 Aug 2012

Abstract excerpt

Mutations of oncogenes and tumor suppressor genes which activate mTOR through several downstream signaling pathways are common to cancer. Activation of mTOR when combined with inhibition of cell cycle progression or DNA replication stress has previously been shown to promote cell senescence. In the present study, we examined the conditions under which human non-small cell lung carcinoma A549 cells can undergo...

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PMID: 22871735
DOI: 10.4161/cc.21506

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