Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility.

doi:10.1007/s00432-025-06226-6

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Article

Investigating the role of the Pon1-rs854560 (L55M) SNP in colorectal Cancer susceptibility.

Journal of cancer research and clinical oncology - 20 May 2025

Wei Xi, Qin Rong, Yin Liang, Iqbal Muhammad Asad, Shaibu Zakari, Li Guorui, Wu Ting

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, with both genetic and environmental risk factors. The PON1 rs854560 (L55M) polymorphism has been implicated in cancer susceptibility through its role in oxidative stress regulation, but its association with CRC remains unclear, particularly in Asian populations. AIM: This study aimed to investigate the association...

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PMID: 40389753
DOI: 10.1007/s00432-025-06226-6
PMCID: PMC12089196

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PON1

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