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Article

Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology.

Disease models & mechanisms - 1 Jan 2013

Monk Kelly R, Voas Matthew G, Franzini-Armstrong Clara, Hakkinen Ian S, Talbot William S

Abstract excerpt

Mutations in SEC63 cause polycystic liver disease in humans. Sec63 is a member of the endoplasmic reticulum (ER) translocon machinery, although it is unclear how mutations in SEC63 lead to liver cyst formation in humans. Here, we report the identification and characterization of a zebrafish sec63...

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Source

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Identifiers

PMID: 22864019
DOI: 10.1242/dmm.009217
PMCID: PMC3529346

Genes

SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22864019-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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