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Article

Polycystic liver disease is a disorder of cotranslational protein processing.

Trends in molecular medicine - 1 Jan 2005

Drenth Joost P H, Martina Jose A, van de Kerkhof Rolf, Bonifacino Juan S, Jansen Jan B M J

Abstract excerpt

Autosomal-dominant polycystic liver disease (PCLD) is a rare disorder that is characterized by the progressive development of fluid-filled biliary epithelial cysts in the liver. Positional cloning has identified two genes that are mutated in patients with polycystic liver disease, PRKCSH and SEC63, which encode the beta-subunit of glucosidase II and Sec63, respectively. Both proteins are components of the...

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Source

Identifiers

PMID: 15649821
DOI: 10.1016/j.molmed.2004.11.004

Genes

PRKCSH
SEC63

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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