Article
Identification of Tau and SOD1 gene mutation in a small Chinese Han pedigree of adult amyotrophic lateral sclerosis.
Neurocase - 1 Jan 2013
Xu Renshi, Shao Bei, Wu Chengsi, Yang Yunzhu, Wang Hanmin, Yang Rongwei, Zhang Xiong, Yi Juan, Liu Jingjing
Abstract excerpt
We report the clinical profile, and a brief investigation of SOD1 and Tau gene mutation from a small Chinese Han pedigree of adults with amyotrophic lateral sclerosis (ALS), which consisted of 32 familial members with 6 affected individuals spanning five generations, and presenting autosomal dominant genetic mode. The mean age of onset was 36.6 ± 15.9 years, and disease duration was 6 months to more than 5 years,...
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