Article
Human RHOH deficiency causes T cell defects and susceptibility to EV-HPV infections.
The Journal of clinical investigation - 1 Sept 2012
Crequer Amandine, Troeger Anja, Patin Etienne, Ma Cindy S, Picard Capucine, Pedergnana Vincent, Fieschi Claire, Lim Annick, Abhyankar Avinash, Gineau Laure, Mueller-Fleckenstein Ingrid, Schmidt Monika, Taieb Alain, Krueger James, Abel Laurent, Tangye Stuart G, Orth Gérard, Williams David A, Casanova Jean-Laurent, Jouanguy Emmanuelle
Abstract excerpt
Epidermodysplasia verruciformis (EV) is a rare genetic disorder characterized by increased susceptibility to specific human papillomaviruses, the betapapillomaviruses. These EV-HPVs cause warts and increase the risk of skin carcinomas in otherwise healthy individuals. Inactivating mutations in epidermodysplasia verruciformis 1 (EVER1) or EVER2 have been identified in most, but not all, patients with autosomal...
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