Prenatal pharmacotherapy rescues brain development in a Down’s syndrome mouse model

Abstract excerpt

Intellectual impairment is a strongly disabling feature of Down's syndrome, a genetic disorder of high prevalence (1 in 700-1000 live births) caused by trisomy of chromosome 21. Accumulating evidence shows that widespread neurogenesis impairment is a major determinant of abnormal brain development and, hence, of intellectual disability in Down's syndrome. This defect is worsened by dendritic hypotrophy and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cerebral Palsy and Movement Disorders
• Share to Down syndrome and intellectual disability research
• Share to Family and Disability Support Research