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Article

Memantine normalizes several phenotypic features in the Ts65Dn mouse model of Down syndrome.

Journal of Alzheimer's disease : JAD - 1 Jan 2010

Rueda Noemí, Llorens-Martín María, Flórez Jesús, Valdizán Elsa, Banerjee Pradeep, Trejo Jose Luis, Martínez-Cué Carmen

Abstract excerpt

Ts65Dn (TS) mice exhibit several phenotypic characteristics of human Down syndrome, including an increased brain expression of amyloid-beta protein precursor (AbetaPP) and cognitive disturbances. Aberrant N-methyl-D-aspartate (NMDA) receptor signaling has been suspected in TS mice, due to an impaired generation of hippocampal long-term potentiation (LTP). Memantine, an uncompetitive NMDA receptor antagonist...

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Identifiers

PMID: 20421694
DOI: 10.3233/JAD-2010-100240

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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